Cardinals vs. Padres Prediction: San Diego Predicted to Win Saturday's MLB Matchup [8/2/2025]

The San Diego Padres will face the St. Louis Cardinals in MLB action at PETCO Park on Saturday, commencing at 10:10PM ET.

The Padres will have Randy Vásquez (3-4, 3.65 ERA) as their starting pitcher, while the Cardinals have opted for Michael McGreevy (2-2, 4.91 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Cardinals vs. Padres predictions page.

Padres vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the result of Saturday's MLB matchup between the Cardinals and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Padres a 59% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 60% chance of covering the run line, while the 8.5-run over/under has a 54% chance of going over.

Cardinals vs. Padres Odds [8/2/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Padres
Run Line	+1.5 (-160)	-1.5 (+142)
Moneyline	+135	-146
Total	o8.5 (-118)	u8.5 (+105)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Padres Picks and Best Bets

Our model's strongest edge in today's Cardinals vs. Padres matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Cardinals vs. Padres Game-Day Updates and Essential Details

Saturday's MLB action between the Padres and Cardinals at PETCO Park is scheduled to commence at 10:10PM ET.

• Who: St. Louis Cardinals vs. San Diego Padres
• Date: Saturday, August 2, 2025
• Time: 10:10PM ET/7:10PM PT
• Venue: PETCO Park

Dimers.com's full preview of Saturday's Cardinals vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 59% win probability, will likely beat the Cardinals on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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