Cardinals vs. Padres Prediction: San Diego Predicted to Win Friday's MLB Matchup [8/1/2025]

The San Diego Padres will square off with the St. Louis Cardinals in MLB action at PETCO Park on Friday, starting at 9:40PM ET.

Nick Pivetta (10-3, 2.81 ERA) will get the ball for the Padres, up against Matthew Liberatore (6-8, 4.04 ERA) for the Cardinals.

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Padres as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Cardinals vs. Padres predictions page.

Padres vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the result of Friday's MLB game between the Cardinals and Padres 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Padres a 65% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 53% chance of covering the run line, while the over/under total of 7.5 runs has an equal 50-50 chance of hitting.

Cardinals vs. Padres Odds [8/1/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Padres
Run Line	+1.5 (-115)	-1.5 (+104)
Moneyline	+176	-207
Total	o7.5 (-104)	u7.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Padres Picks and Best Bets

Our model's strongest edge in today's Cardinals vs. Padres matchup is on the total.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Cardinals vs. Padres Game-Day Updates and Essential Details

Friday's MLB action between the Padres and Cardinals at PETCO Park is scheduled to begin at 9:40PM ET.

• Who: St. Louis Cardinals vs. San Diego Padres
• Date: Friday, August 1, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's comprehensive preview of Friday's Cardinals vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 65% win probability, will likely beat the Cardinals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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