Cardinals vs. Phillies Prediction: Philadelphia Predicted to Win Wednesday's MLB Matchup [5/14/2025]

MLB action continues on Wednesday at 1:05PM ET as the St. Louis Cardinals lock horns with the Philadelphia Phillies at Citizens Bank Park.

Aaron Nola (1-6, 4.89 ERA) will start for the Phillies, up against Erick Fedde (3-3, 3.86 ERA) for the Cardinals.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Phillies as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's St. Louis-Philadelphia game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Phillies' chance of winning at 60%, with the Cardinals at 40%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Cardinals vs. Phillies predictions page.

Phillies vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data analysis, we have simulated the result of Wednesday's MLB game between the Cardinals and Phillies 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Phillies a 60% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 58% chance of covering the run line, while the 8-run over/under has a 56% chance of going over.

Cardinals vs. Phillies Odds [5/14/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Phillies
Run Line	+1.5 (-176)	-1.5 (+150)
Moneyline	+120	-135
Total	o8 (-110)	u8 (-105)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Cardinals vs. Phillies Picks and Best Bets

Our model's strongest edge in today's Cardinals vs. Phillies matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Cardinals vs. Phillies Game-Day Updates and Essential Details

Wednesday's MLB game between the Phillies and Cardinals at Citizens Bank Park is scheduled to commence at 1:05PM ET.

• Who: St. Louis Cardinals vs. Philadelphia Phillies
• Date: Wednesday, May 14, 2025
• Time: 1:05PM ET/10:05AM PT
• Venue: Citizens Bank Park

Dimers.com's comprehensive preview of Wednesday's Cardinals vs. Phillies matchup includes our prediction, picks and the latest betting odds.

Before making any St. Louis vs. Philadelphia picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Phillies, with a 60% win probability, will likely beat the Cardinals on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Phillies insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the most accurate predictions for the World Series, American League, National League and each division.