Cardinals vs. Brewers prediction: Why Milwaukee is favored to win Sunday's MLB matchup [9/14/2025]

The Milwaukee Brewers and St. Louis Cardinals will lock horns in MLB action at American Family Field on Sunday, starting at 2:10PM ET.

Jose Quintana (11-6, 3.88 ERA) will start on the mound for the Brewers, while the Cardinals are going with Miles Mikolas (7-10, 4.84 ERA).

Based on the latest simulation results, Dimers' advanced MLB model predicts the Brewers as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Cardinals-Brewers game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Brewers with a win probability of 64%, while the Cardinals have 36%."

For a closer look at Sunday's matchup, including best bets and picks, visit our interactive Cardinals vs. Brewers predictions page.

Brewers vs. Cardinals prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Sunday's MLB matchup between the Cardinals and Brewers 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Brewers a 64% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 54% chance of covering the run line, while the 8.5-run over/under has a 54% chance of going over.

Cardinals vs. Brewers odds [9/14/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Brewers
Run Line	+1.5 (-125)	-1.5 (+106)
Moneyline	+170	-198
Total	o8.5 (-118)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Cardinals vs. Brewers picks and best bets

Our model's biggest edge in today's Cardinals vs. Brewers matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Cardinals vs. Brewers game-day updates and essential details

Sunday's MLB game between the Brewers and Cardinals at American Family Field is scheduled to commence at 2:10PM ET.

• Who: St. Louis Cardinals vs. Milwaukee Brewers
• Date: Sunday, September 14, 2025
• Time: 2:10PM ET/11:10AM PT
• Venue: American Family Field

Dimers' full preview of Sunday's Cardinals vs. Brewers matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Brewers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Plus, with sports betting in Missouri set to launch on December 1, 2025, Dimers has everything you need—from the latest updates and the best pre-registration offers in MO.

Sports betting deal available for Maryland sports fans

To make the most of Sunday's massive day of sports, headlined by NFL Sunday action, check out details on the latest Bet365 bonus code "DIMERS" that grants you $300 in bonus bets from a $5 bet — win or lose.

Plus, find out all the details on the Bet365 Kansas offer which provides a great option for those in the The Sunflower State. Don't miss out!

Conclusion

We predict the Brewers, with a 64% win probability, will likely beat the Cardinals on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Brewers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds offer the most up-to-date projections for the World Series, American League, National League and each division.