Cardinals vs. Brewers prediction: Why Milwaukee is favored to win Saturday's MLB matchup [9/13/2025]

The Milwaukee Brewers will take on the St. Louis Cardinals in MLB action at American Family Field on Saturday, commencing at 8:15PM ET.

Jacob Misiorowski (5-2, 4.09 ERA) will be the starting pitcher for the Brewers, up against Sonny Gray (13-8, 4.45 ERA) for the Cardinals.

Based on updated simulations, Dimers' proven MLB model predicts the Brewers as the most likely winner of today's game.

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Cardinals vs. Brewers predictions page.

Brewers vs. Cardinals prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the outcome of Saturday's MLB matchup between the Cardinals and Brewers 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Brewers a 59% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 59% chance of covering the run line, while the over/under total of 7.5 runs has a 55% chance of going over.

Cardinals vs. Brewers odds [9/13/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Brewers
Run Line	+1.5 (-138)	-1.5 (+120)
Moneyline	+154	-184
Total	o7.5 (-115)	u7.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Brewers picks and best bets

Our model's strongest edge in today's Cardinals vs. Brewers matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Cardinals vs. Brewers game-day updates and essential details

Saturday's MLB action between the Brewers and Cardinals at American Family Field is scheduled to commence at 8:15PM ET.

• Who: St. Louis Cardinals vs. Milwaukee Brewers
• Date: Saturday, September 13, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: American Family Field

Dimers' comprehensive preview of Saturday's Cardinals vs. Brewers matchup includes our prediction, picks and the latest betting odds.

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Conclusion

We predict the Brewers, with a 59% win probability, will likely beat the Cardinals on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Brewers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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