Cardinals vs. Brewers prediction: Why Milwaukee is favored to win Friday's MLB matchup [9/12/2025]

The Milwaukee Brewers will take on the St. Louis Cardinals in MLB action at American Family Field on Friday, starting at 8:10PM ET.

Quinn Priester (12-2, 3.25 ERA) will be on the bump for the Brewers, while the Cardinals have opted for Andre Pallante (6-13, 5.28 ERA).

Based on updated simulation results, Dimers' advanced MLB model predicts the Brewers as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Cardinals vs. Brewers predictions page.

Brewers vs. Cardinals prediction: Who will win, cover the run line?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Friday's MLB game between the Cardinals and Brewers 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Brewers a 60% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 57% chance of covering the run line, while the over/under total of 8.5 runs has an equal 50-50 chance of hitting.

Cardinals vs. Brewers odds [9/12/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Brewers
Run Line	+1.5 (-124)	-1.5 (+110)
Moneyline	+158	-185
Total	o8.5 (+100)	u8.5 (-119)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Brewers picks and best bets

Our model's strongest edge in today's Cardinals vs. Brewers matchup is on the total.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Cardinals vs. Brewers game-day updates and essential details

Friday's MLB game between the Brewers and Cardinals at American Family Field is scheduled to begin at 8:10PM ET.

• Who: St. Louis Cardinals vs. Milwaukee Brewers
• Date: Friday, September 12, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: American Family Field

Dimers' comprehensive preview of Friday's Cardinals vs. Brewers matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Brewers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Brewers, with a 60% win probability, will likely beat the Cardinals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Brewers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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