Cardinals vs. Marlins prediction: Miami predicted to win Wednesday's MLB matchup [8/20/2025]

The Miami Marlins will take on the St. Louis Cardinals in MLB action at loanDepot park on Wednesday, starting at 6:40PM ET.

Sandy Alcantara (6-11, 6.31 ERA) will start for the Marlins, up against Andre Pallante (6-10, 5.04 ERA) for the Cardinals.

Based on the latest simulation results, Dimers' proven MLB model predicts the Marlins as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Cardinals-Marlins game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Marlins' chance of winning at 51%, with the Cardinals at 49%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Cardinals vs. Marlins predictions page.

Marlins vs. Cardinals prediction: Who will win?

Using innovative machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Cardinals and Marlins 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Marlins a 51% chance of beating the Cardinals.

According to our model, the over/under total of 8.5 runs has a 54% chance of staying under.

Cardinals vs. Marlins odds [8/20/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Marlins
Moneyline	-104	-112
Total	o8.5 (-102)	u8.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Marlins picks and best bets

Our model's biggest edge in today's Cardinals vs. Marlins matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Cardinals vs. Marlins game-day updates and essential details

Wednesday's MLB action between the Marlins and Cardinals at loanDepot park is scheduled to start at 6:40PM ET.

• Who: St. Louis Cardinals vs. Miami Marlins
• Date: Wednesday, August 20, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: loanDepot park

Dimers.com's in-depth preview of Wednesday's Cardinals vs. Marlins matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Marlins picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Marlins, with a 51% win probability, will likely beat the Cardinals on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Marlins insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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