Cardinals vs. Royals Prediction: Kansas City Predicted to Win Saturday's MLB Matchup [5/17/2025]

The Kansas City Royals will face the St. Louis Cardinals in MLB action at Kauffman Stadium on Saturday, starting at 7:10PM ET.

Noah Cameron (1-0, 0.00 ERA) will start for the Royals, pitting him against Miles Mikolas (2-2, 4.35 ERA) for the Cardinals.

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Royals as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's St. Louis-Kansas City game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Royals are more likely to win, while the Cardinals have a lower chance of victory."

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Cardinals vs. Royals predictions page.

Royals vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the outcome of Saturday's MLB game between the Cardinals and Royals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Royals a 54% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 63% chance of covering the run line, while the over/under total of 9 runs has a 53% chance of staying under.

Cardinals vs. Royals Odds [5/17/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Royals
Run Line	+1.5 (-210)	-1.5 (+160)
Moneyline	-104	-112
Total	o9 (-115)	u9 (-105)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Royals Picks and Best Bets

Our model's strongest edge in today's Cardinals vs. Royals matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Cardinals vs. Royals Game-Day Updates and Essential Details

Saturday's MLB game between the Royals and Cardinals at Kauffman Stadium is scheduled to commence at 7:10PM ET.

• Who: St. Louis Cardinals vs. Kansas City Royals
• Date: Saturday, May 17, 2025
• Time: 7:10PM ET/4:10PM PT
• Venue: Kauffman Stadium

Dimers.com's full preview of Saturday's Cardinals vs. Royals matchup includes our prediction, picks and the latest betting odds.

Before making any St. Louis vs. Kansas City picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Royals, with a 54% win probability, will likely beat the Cardinals on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Royals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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