Cardinals vs. Rockies Prediction: St. Louis Predicted to Win Tuesday's MLB Matchup [7/22/2025]

The Colorado Rockies and St. Louis Cardinals are scheduled to meet in MLB action at Coors Field on Tuesday, starting at 8:40PM ET.

Bradley Blalock (0-2, 9.97 ERA) will be on the bump for the Rockies, while the Cardinals have opted for Erick Fedde (3-9, 4.83 ERA).

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cardinals as the most likely winner of today's game.

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Cardinals vs. Rockies predictions page.

Rockies vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Tuesday's MLB matchup between the Cardinals and Rockies 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Cardinals a 59% chance of beating the Rockies.

According to our model, the Rockies (+1.5) have a 53% chance of covering the run line, while the 12-run over/under has a 55% chance of staying under.

Cardinals vs. Rockies Odds [7/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Rockies
Run Line	-1.5 (-110)	+1.5 (-105)
Moneyline	-162	+142
Total	o12 (-104)	u12 (-115)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Cardinals vs. Rockies Picks and Best Bets

Our model's biggest edge in today's Cardinals vs. Rockies matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Cardinals vs. Rockies Game-Day Updates and Essential Details

Tuesday's MLB matchup between the Rockies and Cardinals at Coors Field is scheduled to commence at 8:40PM ET.

• Who: St. Louis Cardinals vs. Colorado Rockies
• Date: Tuesday, July 22, 2025
• Time: 8:40PM ET/5:40PM PT
• Venue: Coors Field

Dimers.com's full preview of Tuesday's Cardinals vs. Rockies matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Rockies picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Plus, with Missouri sports betting set to launch on December 1, 2025, Dimers has everything you need—from the latest news and the best MO sports betting promos.

Conclusion

We predict the Cardinals, with a 59% win probability, will likely beat the Rockies on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Rockies insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest probabilities for the World Series, American League, National League and each division.