Cardinals vs. Rockies Prediction: St. Louis Predicted to Win Monday's MLB Matchup [7/21/2025]

The Colorado Rockies will square off with the St. Louis Cardinals in MLB action at Coors Field on Monday, commencing at 8:40PM ET.

Austin Gomber (0-3, 5.65 ERA) will be the starting pitcher for the Rockies, pitting him against Michael McGreevy (1-1, 4.22 ERA) for the Cardinals.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Cardinals as the most likely winner of today's game.

For expanded analysis of Monday's matchup, including best bets and picks, visit our interactive Cardinals vs. Rockies predictions page.

Rockies vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the result of Monday's MLB game between the Cardinals and Rockies 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Cardinals a 59% chance of defeating the Rockies.

According to our model, the Rockies (+1.5) have a 52% chance of covering the run line, while the 12-run over/under has a 57% chance of staying under.

Cardinals vs. Rockies Odds [7/21/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Rockies
Run Line	-1.5 (-115)	+1.5 (+100)
Moneyline	-168	+150
Total	o12 (-106)	u12 (-115)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Rockies Picks and Best Bets

Our model's biggest edge in today's Cardinals vs. Rockies matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Cardinals vs. Rockies Game-Day Updates and Essential Details

Monday's MLB game between the Rockies and Cardinals at Coors Field is scheduled to begin at 8:40PM ET.

• Who: St. Louis Cardinals vs. Colorado Rockies
• Date: Monday, July 21, 2025
• Time: 8:40PM ET/5:40PM PT
• Venue: Coors Field

Dimers.com's full preview of Monday's Cardinals vs. Rockies matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Rockies picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cardinals, with a 59% win probability, will likely beat the Rockies on Monday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Rockies insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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