Cardinals vs. Guardians Prediction: Tight Battle Projected in Updated Analysis for Sunday's MLB Matchup [6/29/2025]

MLB action continues on Sunday at 12:05PM ET as the St. Louis Cardinals take on the Cleveland Guardians at Progressive Field.

The Guardians will send Logan Allen (5-5, 4.25 ERA) to the mound, while the Cardinals will counter with Matthew Liberatore (5-6, 3.96 ERA).

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts an equal chance for both the Guardians and Cardinals to win today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Cardinals-Guardians game," said Dimers' Chief Content Officer, Nick Slade.

"Based on the latest updates and extensive data, we predict a 50-50 chance for both the Guardians and Cardinals, making it a highly competitive matchup."

For expanded analysis of Sunday's matchup, including best bets and picks, visit our interactive Cardinals vs. Guardians predictions page.

Guardians vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Sunday's MLB matchup between the Cardinals and Guardians 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently can't split the two teams, giving both the Cardinals and Guardians a 50% chance of winning the game.

According to our model, the Guardians (+1.5) have a 63% chance of covering the run line, while the 8-run over/under has an equal 50-50 chance of hitting.

Cardinals vs. Guardians Odds [6/29/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Guardians
Run Line	-1.5 (+146)	+1.5 (-175)
Moneyline	-112	-102
Total	o8 (-114)	u8 (-102)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Guardians Picks and Best Bets

Our model's strongest edge in today's Cardinals vs. Guardians matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Cardinals vs. Guardians Game-Day Updates and Essential Details

Sunday's MLB action between the Guardians and Cardinals at Progressive Field is scheduled to begin at 12:05PM ET.

• Who: St. Louis Cardinals vs. Cleveland Guardians
• Date: Sunday, June 29, 2025
• Time: 12:05PM ET/9:05AM PT
• Venue: Progressive Field

Dimers.com's in-depth preview of Sunday's Cardinals vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict a close game between the Cardinals and Guardians on Sunday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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