Cardinals vs. Guardians Prediction: Cleveland Predicted to Win Saturday's MLB Matchup [6/28/2025]

The Cleveland Guardians will face the St. Louis Cardinals in MLB action at Progressive Field on Saturday, commencing at 4:10PM ET.

The Guardians will start Slade Cecconi (3-3, 3.38 ERA), while the Cardinals have opted for Miles Mikolas (4-5, 4.31 ERA).

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Guardians as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Cardinals-Guardians game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Guardians are more likely to win, while the Cardinals have a lower chance of victory."

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Cardinals vs. Guardians predictions page.

Guardians vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Saturday's MLB matchup between the Cardinals and Guardians 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Guardians a 53% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 65% chance of covering the run line, while the 8-run over/under has a 54% chance of going over.

Cardinals vs. Guardians Odds [6/28/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Guardians
Run Line	+1.5 (-200)	-1.5 (+164)
Moneyline	+104	-120
Total	o8 (-120)	u8 (-101)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Guardians Picks and Best Bets

Our model's strongest edge in today's Cardinals vs. Guardians matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Cardinals vs. Guardians Game-Day Updates and Essential Details

Saturday's MLB action between the Guardians and Cardinals at Progressive Field is scheduled to start at 4:10PM ET.

• Who: St. Louis Cardinals vs. Cleveland Guardians
• Date: Saturday, June 28, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: Progressive Field

Dimers.com's full preview of Saturday's Cardinals vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Guardians, with a 53% win probability, will likely beat the Cardinals on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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