Cardinals vs. Guardians Prediction: St. Louis Predicted to Win Friday's MLB Matchup [6/27/2025]

The Cleveland Guardians and St. Louis Cardinals will meet in MLB action at Progressive Field on Friday, starting at 7:10PM ET.

Luis L. Ortiz (4-8, 4.30 ERA) will be on the bump for the Guardians, pitting him against Sonny Gray (7-2, 3.72 ERA) for the Cardinals.

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cardinals as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Cardinals-Guardians game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Cardinals' chance of winning is 54%, while the Guardians' is 46%."

For further insights into Friday's matchup, including best bets and picks, visit our interactive Cardinals vs. Guardians predictions page.

Guardians vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the result of Friday's MLB game between the Cardinals and Guardians 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Cardinals a 54% chance of beating the Guardians.

According to our model, the Guardians (+1.5) have a 59% chance of covering the run line, while the 8.5-run over/under has an equal 50-50 chance of hitting.

Cardinals vs. Guardians Odds [6/27/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Guardians
Run Line	-1.5 (+134)	+1.5 (-150)
Moneyline	-124	+110
Total	o8.5 (-110)	u8.5 (-105)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Cardinals vs. Guardians Picks and Best Bets

Our model's biggest edge in today's Cardinals vs. Guardians matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Cardinals vs. Guardians Game-Day Updates and Essential Details

Friday's MLB action between the Guardians and Cardinals at Progressive Field is scheduled to commence at 7:10PM ET.

• Who: St. Louis Cardinals vs. Cleveland Guardians
• Date: Friday, June 27, 2025
• Time: 7:10PM ET/4:10PM PT
• Venue: Progressive Field

Dimers.com's full preview of Friday's Cardinals vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Plus, with Missouri sports betting launching on December 1, 2025, Dimers has you covered with the latest news and the best MO sports betting bonuses.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Cardinals, with a 54% win probability, will likely beat the Guardians on Friday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most accurate projections for the World Series, American League, National League and each division.