Cardinals vs. Reds Prediction: Cincinnati Predicted to Win Tuesday's MLB Matchup [4/29/2025]

The Cincinnati Reds will take on the St. Louis Cardinals in MLB action at Great American Ball Park on Tuesday, beginning at 6:40PM ET.

The Reds will send Brady Singer (4-0, 3.62 ERA) to the mound, up against Miles Mikolas (0-2, 5.70 ERA) for the Cardinals.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Reds as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's St. Louis-Cincinnati game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Reds with a win probability of 55%, compared to 45% for the Cardinals."

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Cardinals vs. Reds predictions page.

Reds vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Tuesday's MLB matchup between the Cardinals and Reds 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Reds a 55% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 63% chance of covering the run line, while the over/under total of 9.5 runs has a 54% chance of staying under.

Cardinals vs. Reds Odds [4/29/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Reds
Run Line	+1.5 (-154)	-1.5 (+145)
Moneyline	+126	-148
Total	o9.5 (-105)	u9.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Reds Picks and Best Bets

Our model's biggest edge in today's Cardinals vs. Reds matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Cardinals vs. Reds Game-Day Updates and Essential Details

Tuesday's MLB matchup between the Reds and Cardinals at Great American Ball Park is scheduled to commence at 6:40PM ET.

• Who: St. Louis Cardinals vs. Cincinnati Reds
• Date: Tuesday, April 29, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Great American Ball Park

Dimers.com's comprehensive preview of Tuesday's Cardinals vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any St. Louis vs. Cincinnati picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Reds, with a 55% win probability, will likely beat the Cardinals on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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