Cardinals vs. Reds Prediction: Cincinnati Predicted to Win Tuesday's MLB Matchup [4/29/2025]

The Cincinnati Reds will square off with the St. Louis Cardinals in MLB action at Great American Ball Park on Tuesday, commencing at 6:40PM ET.

Brady Singer (4-0, 3.62 ERA) will be on the bump for the Reds, while the Cardinals have opted for Miles Mikolas (0-2, 5.70 ERA).

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Reds as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's St. Louis-Cincinnati game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Reds with a win probability of 55%, compared to 45% for the Cardinals."

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Cardinals vs. Reds predictions page.

Reds vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Tuesday's MLB game between the Cardinals and Reds 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Reds a 55% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 63% chance of covering the run line, while the over/under total of 9.5 runs has a 54% chance of staying under.

Cardinals vs. Reds Odds [4/29/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Reds
Run Line	+1.5 (-154)	-1.5 (+145)
Moneyline	+126	-148
Total	o9.5 (-105)	u9.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Reds Picks and Best Bets

Our model's strongest edge in today's Cardinals vs. Reds matchup is on the total.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Cardinals vs. Reds Game-Day Updates and Essential Details

Tuesday's MLB matchup between the Reds and Cardinals at Great American Ball Park is scheduled to start at 6:40PM ET.

• Who: St. Louis Cardinals vs. Cincinnati Reds
• Date: Tuesday, April 29, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Great American Ball Park

Dimers.com's full preview of Tuesday's Cardinals vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any St. Louis vs. Cincinnati picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Reds, with a 55% win probability, will likely beat the Cardinals on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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