Cardinals vs. Reds prediction: Why Cincinnati is favored to win Sunday's MLB matchup [8/31/2025]

The Cincinnati Reds and St. Louis Cardinals will meet in MLB action at Great American Ball Park on Sunday, starting at 12:10PM ET.

Brady Singer (11-9, 4.06 ERA) will be on the bump for the Reds, while the Cardinals have opted for Andre Pallante (6-12, 5.44 ERA).

Based on updated simulations, Dimers' proven MLB model projects the Reds as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Cardinals-Reds game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Reds with a win probability of 56%, while the Cardinals have 44%."

For further insights into Sunday's matchup, including best bets and picks, visit our interactive Cardinals vs. Reds predictions page.

Reds vs. Cardinals prediction: Who will win, cover the run line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Sunday's MLB matchup between the Cardinals and Reds 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Reds a 56% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 62% chance of covering the run line, while the over/under total of 8.5 runs has a 51% chance of staying under.

Cardinals vs. Reds odds [8/31/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Reds
Run Line	+1.5 (-176)	-1.5 (+155)
Moneyline	+118	-138
Total	o8.5 (+100)	u8.5 (-122)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Cardinals vs. Reds picks and best bets

Our model's strongest edge in today's Cardinals vs. Reds matchup is on the over/under.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Cardinals vs. Reds game-day updates and essential details

Sunday's MLB action between the Reds and Cardinals at Great American Ball Park is scheduled to commence at 12:10PM ET.

• Who: St. Louis Cardinals vs. Cincinnati Reds
• Date: Sunday, August 31, 2025
• Time: 12:10PM ET/9:10AM PT
• Venue: Great American Ball Park

Dimers.com's in-depth preview of Sunday's Cardinals vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Reds picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Plus, with Missouri sports betting launching on December 1, 2025, Dimers is your go-to source for the latest updates and the best pre-registration offers in MO.

Conclusion

We predict the Reds, with a 56% win probability, will likely beat the Cardinals on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest predictions for the World Series, American League, National League and each division.