Cardinals vs. Reds prediction: Why Cincinnati is favored to win Friday's MLB matchup [8/29/2025]

The Cincinnati Reds and St. Louis Cardinals will lock horns in MLB action at Great American Ball Park on Friday, starting at 6:40PM ET.

The Reds will start Zack Littell (9-8, 3.62 ERA), pitting him against Matthew Liberatore (6-11, 4.27 ERA) for the Cardinals.

Based on updated simulations, Dimers' advanced MLB model predicts the Reds as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Cardinals vs. Reds predictions page.

Reds vs. Cardinals prediction: Who will win, cover the run line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Friday's MLB game between the Cardinals and Reds 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Reds a 54% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 64% chance of covering the run line, while the 9.5-run over/under has a 55% chance of staying under.

Cardinals vs. Reds odds [8/29/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Reds
Run Line	+1.5 (-178)	-1.5 (+154)
Moneyline	+120	-104
Total	o9.5 (-108)	u9.5 (-121)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Reds picks and best bets

Our model's biggest edge in today's Cardinals vs. Reds matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Cardinals vs. Reds game-day updates and essential details

Friday's MLB game between the Reds and Cardinals at Great American Ball Park is scheduled to begin at 6:40PM ET.

• Who: St. Louis Cardinals vs. Cincinnati Reds
• Date: Friday, August 29, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Great American Ball Park

Dimers.com's full preview of Friday's Cardinals vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Reds picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Reds, with a 54% win probability, will likely beat the Cardinals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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