Cardinals vs. White Sox Prediction: St. Louis Predicted to Win Wednesday's MLB Matchup [6/18/2025]

The Chicago White Sox will take on the St. Louis Cardinals in MLB action at Rate Field on Wednesday, commencing at 7:40PM ET.

The White Sox will have Sean Burke (3-7, 4.71 ERA) as their starting pitcher, while the Cardinals have opted for Sonny Gray (7-2, 3.84 ERA).

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Cardinals as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's St. Louis-CHI White Sox game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cardinals' chance of winning at 62%, with the White Sox at 38%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Cardinals vs. White Sox predictions page.

White Sox vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Cardinals and White Sox 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Cardinals a 62% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 51% chance of covering the run line, while the 8.5-run over/under has a 54% chance of staying under.

Cardinals vs. White Sox Odds [6/18/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	White Sox
Run Line	-1.5 (-108)	+1.5 (-105)
Moneyline	-175	+148
Total	o8.5 (-106)	u8.5 (-109)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. White Sox Picks and Best Bets

Our model's strongest edge in today's Cardinals vs. White Sox matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Cardinals vs. White Sox Game-Day Updates and Essential Details

Wednesday's MLB game between the White Sox and Cardinals at Rate Field is scheduled to start at 7:40PM ET.

• Who: St. Louis Cardinals vs. Chicago White Sox
• Date: Wednesday, June 18, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Rate Field

Dimers.com's in-depth preview of Wednesday's Cardinals vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any St. Louis vs. CHI White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cardinals, with a 62% win probability, will likely beat the White Sox on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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