Cardinals vs. White Sox Prediction: St. Louis Predicted to Win Tuesday's MLB Matchup [6/17/2025]

The Chicago White Sox will square off with the St. Louis Cardinals in MLB action at Rate Field on Tuesday, starting at 7:40PM ET.

Shane Smith (3-3, 2.37 ERA) will get the ball for the White Sox, pitting him against Matthew Liberatore (3-6, 4.17 ERA) for the Cardinals.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Cardinals as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's St. Louis-CHI White Sox game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Cardinals with a win probability of 54%, compared to 46% for the White Sox."

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Cardinals vs. White Sox predictions page.

White Sox vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the result of Tuesday's MLB matchup between the Cardinals and White Sox 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Cardinals a 54% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 60% chance of covering the run line, while the 9.5-run over/under has a 59% chance of staying under.

Cardinals vs. White Sox Odds [6/17/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	White Sox
Run Line	-1.5 (+125)	+1.5 (-142)
Moneyline	-132	+115
Total	o9.5 (-102)	u9.5 (-119)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. White Sox Picks and Best Bets

Our model's strongest edge in today's Cardinals vs. White Sox matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Cardinals vs. White Sox Game-Day Updates and Essential Details

Tuesday's MLB game between the White Sox and Cardinals at Rate Field is scheduled to begin at 7:40PM ET.

• Who: St. Louis Cardinals vs. Chicago White Sox
• Date: Tuesday, June 17, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Rate Field

Dimers.com's comprehensive preview of Tuesday's Cardinals vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any St. Louis vs. CHI White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Cardinals, with a 54% win probability, will likely beat the White Sox on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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