Cardinals vs. White Sox Prediction: St. Louis Predicted to Win Thursday's MLB Matchup [6/19/2025]

The Chicago White Sox will square off with the St. Louis Cardinals in MLB action at Rate Field on Thursday, commencing at 2:10PM ET.

Adrian Houser (2-2, 2.15 ERA) will be the starting pitcher for the White Sox, up against Erick Fedde (3-6, 3.65 ERA) for the Cardinals.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Cardinals as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's St. Louis-CHI White Sox game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Cardinals with a win probability of 57% and the White Sox with 43%."

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Cardinals vs. White Sox predictions page.

White Sox vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Thursday's MLB game between the Cardinals and White Sox 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Cardinals a 57% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 57% chance of covering the run line, while the over/under total of 8.5 runs has a 51% chance of staying under.

Cardinals vs. White Sox Odds [6/19/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	White Sox
Run Line	-1.5 (+100)	+1.5 (-118)
Moneyline	-166	+140
Total	o8.5 (-115)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. White Sox Picks and Best Bets

Our model's biggest edge in today's Cardinals vs. White Sox matchup is on the total.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Cardinals vs. White Sox Game-Day Updates and Essential Details

Thursday's MLB game between the White Sox and Cardinals at Rate Field is scheduled to start at 2:10PM ET.

• Who: St. Louis Cardinals vs. Chicago White Sox
• Date: Thursday, June 19, 2025
• Time: 2:10PM ET/11:10AM PT
• Venue: Rate Field

Dimers.com's comprehensive preview of Thursday's Cardinals vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any St. Louis vs. CHI White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cardinals, with a 57% win probability, will likely beat the White Sox on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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