Cardinals vs. Cubs prediction: Why Cubs are favored to win Sunday's MLB matchup [9/28/2025]

The Chicago Cubs will take on the St. Louis Cardinals in MLB action at Wrigley Field on Sunday, commencing at 3:20PM ET.

Javier Assad (3-1, 4.26 ERA) will start on the mound for the Cubs, while the Cardinals will counter with Kyle Leahy (4-2, 3.18 ERA).

Based on updated simulation results, Dimers' proven MLB model projects the Cubs as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Cardinals-Cubs game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Cubs with a win probability of 58%, while the Cardinals have 42%."

For a closer look at Sunday's matchup, including best bets and picks, visit our interactive Cardinals vs. Cubs predictions page.

Cubs vs. Cardinals prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the result of Sunday's MLB matchup between the Cardinals and Cubs 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Cubs a 58% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 61% chance of covering the run line, while the over/under total of 7 runs has a 64% chance of going over.

Cardinals vs. Cubs odds [9/28/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Cubs
Run Line	+1.5 (-172)	-1.5 (+155)
Moneyline	+127	-148
Total	o7 (-111)	u7 (+100)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Cubs picks and best bets

Our model's biggest edge in today's Cardinals vs. Cubs matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

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Cardinals vs. Cubs game-day updates and essential details

Sunday's MLB game between the Cubs and Cardinals at Wrigley Field is scheduled to begin at 3:20PM ET.

• Who: St. Louis Cardinals vs. Chicago Cubs
• Date: Sunday, September 28, 2025
• Time: 3:20PM ET/12:20PM PT
• Venue: Wrigley Field

Dimers' comprehensive preview of Sunday's Cardinals vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 58% win probability, will likely beat the Cardinals on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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