Cardinals vs. Cubs prediction: Why Cubs are favored to win Saturday's MLB matchup [9/27/2025]

The Chicago Cubs will square off with the St. Louis Cardinals in MLB action at Wrigley Field on Saturday, commencing at 2:20PM ET.

The Cubs will send Jameson Taillon (10-7, 3.78 ERA) to the mound, up against Michael McGreevy (8-3, 4.35 ERA) for the Cardinals.

Based on updated simulation results, Dimers' proven MLB model predicts the Cubs as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Cardinals vs. Cubs predictions page.

Cubs vs. Cardinals prediction: Who will win, cover the run line?

Using trusted machine learning and data analysis, we have simulated the outcome of Saturday's MLB game between the Cardinals and Cubs 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Cubs a 60% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 57% chance of covering the run line, while the over/under total of 9.5 runs has a 55% chance of going over.

Cardinals vs. Cubs odds [9/27/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Cubs
Run Line	+1.5 (-130)	-1.5 (+114)
Moneyline	+150	-178
Total	o9.5 (-106)	u9.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Cubs picks and best bets

Our model's biggest edge in today's Cardinals vs. Cubs matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Cardinals vs. Cubs game-day updates and essential details

Saturday's MLB action between the Cubs and Cardinals at Wrigley Field is scheduled to start at 2:20PM ET.

• Who: St. Louis Cardinals vs. Chicago Cubs
• Date: Saturday, September 27, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers' in-depth preview of Saturday's Cardinals vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 60% win probability, will likely beat the Cardinals on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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