Cardinals vs. Cubs prediction: Why Cubs are favored to win Friday's MLB matchup [9/26/2025]

The Chicago Cubs will take on the St. Louis Cardinals in MLB action at Wrigley Field on Friday, commencing at 2:20PM ET.

The Cubs will have Colin Rea (10-7, 4.10 ERA) as their starting pitcher, up against Miles Mikolas (8-10, 4.76 ERA) for the Cardinals.

Based on updated simulations, Dimers' proven MLB model predicts the Cubs as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Cardinals vs. Cubs predictions page.

Cubs vs. Cardinals prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the result of Friday's MLB game between the Cardinals and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cubs a 62% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 55% chance of covering the run line, while the over/under total of 9 runs has a 57% chance of going over.

Cardinals vs. Cubs odds [9/26/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Cubs
Run Line	+1.5 (-120)	-1.5 (+110)
Moneyline	+176	-181
Total	o9 (+100)	u9 (-118)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Cubs picks and best bets

Our model's strongest edge in today's Cardinals vs. Cubs matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Cardinals vs. Cubs game-day updates and essential details

Friday's MLB matchup between the Cubs and Cardinals at Wrigley Field is scheduled to begin at 2:20PM ET.

• Who: St. Louis Cardinals vs. Chicago Cubs
• Date: Friday, September 26, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers' comprehensive preview of Friday's Cardinals vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 62% win probability, will likely beat the Cardinals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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