Cardinals vs. Cubs Prediction: Cubs Predicted to Win Sunday's MLB Matchup [7/6/2025]

The Chicago Cubs will take on the St. Louis Cardinals in MLB action at Wrigley Field on Sunday, beginning at 6:10PM ET.

Matthew Boyd (8-3, 2.64 ERA) will be on the bump for the Cubs, while the Cardinals are going with Erick Fedde (3-8, 4.56 ERA).

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Cubs as the most likely winner of today's game. "Using the most recent data, our experts ran 10,000 simulations of Sunday's Cardinals-Cubs game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Cubs with a win probability of 65%, while the Cardinals have 35%."

For expanded analysis of Sunday's matchup, including best bets and picks, visit our interactive Cardinals vs. Cubs predictions page.

Cubs vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Sunday's MLB game between the Cardinals and Cubs 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Cubs a 65% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 54% chance of covering the run line, while the 7-run over/under has a 56% chance of going over.

Cardinals vs. Cubs Odds [7/6/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Cubs
Run Line	+1.5 (-110)	-1.5 (+100)
Moneyline	+188	-215
Total	o7 (-114)	u7 (+100)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Cubs Picks and Best Bets

Our model's biggest edge in today's Cardinals vs. Cubs matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Cardinals vs. Cubs Game-Day Updates and Essential Details

Sunday's MLB game between the Cubs and Cardinals at Wrigley Field is scheduled to start at 6:10PM ET.

• Who: St. Louis Cardinals vs. Chicago Cubs
• Date: Sunday, July 6, 2025
• Time: 6:10PM ET/3:10PM PT
• Venue: Wrigley Field

Dimers.com's in-depth preview of Sunday's Cardinals vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Plus, with Missouri sports betting set to launch on December 1, 2025, Dimers is your go-to source for the latest news and the best MO sports betting bonuses.

Conclusion

We predict the Cubs, with a 65% win probability, will likely beat the Cardinals on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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