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Cardinals vs. Orioles Prediction: Baltimore Predicted to Win Wednesday's MLB Matchup [5/28/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Our expert prediction for Wednesday's St. Louis Cardinals vs Baltimore Orioles matchup.
The Baltimore Orioles will face the St. Louis Cardinals in MLB action at Oriole Park at Camden Yards on Wednesday, beginning at 6:35PM ET.
Cade Povich (1-3, 4.86 ERA) will start on the mound for the Orioles, while the Cardinals are going with Miles Mikolas (4-2, 3.51 ERA).
Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Orioles as the most likely winner of today's game.
"Our team has simulated the outcome of Wednesday's St. Louis-Baltimore game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.
"With the latest updates and numerous other variables, we estimate the Orioles' chance of winning at 55%, with the Cardinals at 45%."
For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Cardinals vs. Orioles predictions page.
Orioles vs. Cardinals Prediction: Who Will Win, Cover the Run Line?
Using trusted machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Cardinals and Orioles 10,000 times as part of our MLB predictions coverage.
Our leading predictive model gives the Orioles a 55% chance of beating the Cardinals.
According to our model, the Cardinals (+1.5) have a 62% chance of covering the run line, while the over/under total of 7.5 runs has a 54% chance of going over.
Cardinals vs. Orioles Odds [5/28/2025]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Cardinals | Orioles |
|---|---|---|
| Run Line | +1.5 (-225) | -1.5 (+170) |
| Moneyline | +102 | -112 |
| Total | o7.5 (-118) | u7.5 (+100) |
All odds are correct at the time of publication and are subject to change.
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Cardinals vs. Orioles Picks and Best Bets
Our model's strongest edge in today's Cardinals vs. Orioles matchup is on the moneyline.
Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our full set of picks, including this one, is available via Dimers Pro.
Calling Our Shot's Free ⚾️ Picks
Calling Our Shot produces daily MLB betting content, including the best bets featured below.
Cardinals vs. Orioles Game-Day Updates and Essential Details
Wednesday's MLB action between the Orioles and Cardinals at Oriole Park at Camden Yards is scheduled to commence at 6:35PM ET.
- Who: St. Louis Cardinals vs. Baltimore Orioles
- Date: Wednesday, May 28, 2025
- Time: 6:35PM ET/3:35PM PT
- Venue: Oriole Park at Camden Yards
Dimers.com's comprehensive preview of Wednesday's Cardinals vs. Orioles matchup includes our prediction, picks and the latest betting odds.
Before making any St. Louis vs. Baltimore picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Key MLB Betting Guides and Insights
- Explore how MLB odds work and dive into MLB live betting strategies
- Understand where sports odds come from and how they're applied to baseball matchups
- Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
- Stay informed with where online sports betting is currently legal and which betting sites are safest to use
- Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on
Conclusion
We predict the Orioles, with a 55% win probability, will likely beat the Cardinals on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on MLB
Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest probabilities for the World Series, American League, National League and each division.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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