Cardinals vs. Orioles Prediction: St. Louis Predicted to Win Tuesday's MLB Matchup [5/27/2025]

MLB action continues on Tuesday at 6:35PM ET as the St. Louis Cardinals lock horns with the Baltimore Orioles at Oriole Park at Camden Yards.

Tomoyuki Sugano (4-3, 3.07 ERA) will be the starting pitcher for the Orioles, while the Cardinals have opted for Andre Pallante (4-3, 4.18 ERA).

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cardinals as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's St. Louis-Baltimore game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Cardinals with a win probability of 51%, compared to 49% for the Orioles."

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Cardinals vs. Orioles predictions page.

Orioles vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data analysis, we have simulated the outcome of Tuesday's MLB game between the Cardinals and Orioles 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cardinals a 51% chance of defeating the Orioles.

According to our model, the Orioles (+1.5) have a 61% chance of covering the run line, while the over/under total of 8.5 runs has a 53% chance of going over.

Cardinals vs. Orioles Odds [5/27/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Orioles
Run Line	-1.5 (+140)	+1.5 (-156)
Moneyline	-124	+106
Total	o8.5 (-110)	u8.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Orioles Picks and Best Bets

Our model's strongest edge in today's Cardinals vs. Orioles matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Cardinals vs. Orioles Game-Day Updates and Essential Details

Tuesday's MLB game between the Orioles and Cardinals at Oriole Park at Camden Yards is scheduled to start at 6:35PM ET.

• Who: St. Louis Cardinals vs. Baltimore Orioles
• Date: Tuesday, May 27, 2025
• Time: 6:35PM ET/3:35PM PT
• Venue: Oriole Park at Camden Yards

Dimers.com's in-depth preview of Tuesday's Cardinals vs. Orioles matchup includes our prediction, picks and the latest betting odds.

Before making any St. Louis vs. Baltimore picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cardinals, with a 51% win probability, will likely beat the Orioles on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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