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Cardinals vs. Diamondbacks Prediction: Arizona Predicted to Win Sunday's MLB Matchup [7/20/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Our expert prediction for Sunday's St. Louis Cardinals vs Arizona Diamondbacks matchup.
The Arizona Diamondbacks and St. Louis Cardinals will meet in MLB action at Chase Field on Sunday, starting at 4:10PM ET.
The Diamondbacks will have Merrill Kelly (8-5, 3.34 ERA) as their starting pitcher, while the Cardinals will counter with Miles Mikolas (5-6, 4.94 ERA).
Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Diamondbacks as the most likely winner of today's game.
"Using the most recent data, our experts ran 10,000 simulations of Sunday's Cardinals-Diamondbacks game," said Dimers' Chief Content Officer, Nick Slade.
"After accounting for recent updates and other variables, our prediction shows the Diamondbacks with a win probability of 57%, while the Cardinals have 43%."
For expanded analysis of Sunday's matchup, including best bets and picks, visit our interactive Cardinals vs. Diamondbacks predictions page.
Diamondbacks vs. Cardinals Prediction: Who Will Win, Cover the Run Line?
Using powerful machine learning and data, we have simulated the outcome of Sunday's MLB matchup between the Cardinals and Diamondbacks 10,000 times as part of our MLB predictions coverage.
Our famous predictive model currently gives the Diamondbacks a 57% chance of beating the Cardinals.
According to our model, the Cardinals (+1.5) have a 60% chance of covering the run line, while the 9-run over/under has an equal 50-50 chance of hitting.
Cardinals vs. Diamondbacks Odds [7/20/2025]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Cardinals | Diamondbacks |
|---|---|---|
| Run Line | +1.5 (-166) | -1.5 (+145) |
| Moneyline | +122 | -140 |
| Total | o9 (+100) | u9 (-118) |
All odds are correct at the time of publication and are subject to change.
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Cardinals vs. Diamondbacks Picks and Best Bets
Our model's strongest edge in today's Cardinals vs. Diamondbacks matchup is on the run line.
Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our full set of picks, including this one, is available via Dimers Pro.
Calling Our Shot's Free MLB Picks
Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.
Cardinals vs. Diamondbacks Game-Day Updates and Essential Details
Sunday's MLB game between the Diamondbacks and Cardinals at Chase Field is scheduled to begin at 4:10PM ET.
- Who: St. Louis Cardinals vs. Arizona Diamondbacks
- Date: Sunday, July 20, 2025
- Time: 4:10PM ET/1:10PM PT
- Venue: Chase Field
Dimers.com's in-depth preview of Sunday's Cardinals vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.
Before making any Cardinals vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Plus, with Missouri sports betting set to launch on December 1, 2025, Dimers is your trusted source for the latest news and the best pre-registration offers in MO.
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Conclusion
We predict the Diamondbacks, with a 57% win probability, will likely beat the Cardinals on Sunday.
AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on MLB
Keep up with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most up-to-date predictions for the World Series, American League, National League and each division.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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