Cardinals vs. Diamondbacks Prediction: Tight Battle Projected in Updated Analysis for Friday's MLB Matchup [7/18/2025]

The Arizona Diamondbacks and St. Louis Cardinals will meet in MLB action at Chase Field on Friday, starting at 9:40PM ET.

Brandon Pfaadt (9-6, 5.16 ERA) will get the ball for the Diamondbacks, while the Cardinals have opted for Andre Pallante (5-5, 4.48 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts an equal chance for both the Diamondbacks and Cardinals to win today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Cardinals vs. Diamondbacks predictions page.

Diamondbacks vs. Cardinals Prediction: Who Will Win?

Using powerful machine learning and data analysis, we have simulated the result of Friday's MLB matchup between the Cardinals and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently can't split the two teams, giving both the Cardinals and Diamondbacks a 50% chance of winning the game.

According to our model, the over/under total of 8.5 runs has a 52% chance of going over.

Cardinals vs. Diamondbacks Odds [7/18/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Diamondbacks
Moneyline	-106	-110
Total	o8.5 (-118)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Cardinals vs. Diamondbacks Picks and Best Bets

Our model's biggest edge in today's Cardinals vs. Diamondbacks matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Cardinals vs. Diamondbacks Game-Day Updates and Essential Details

Friday's MLB action between the Diamondbacks and Cardinals at Chase Field is scheduled to commence at 9:40PM ET.

• Who: St. Louis Cardinals vs. Arizona Diamondbacks
• Date: Friday, July 18, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: Chase Field

Dimers.com's comprehensive preview of Friday's Cardinals vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Plus, with sports betting in Missouri set to launch on December 1, 2025, Dimers has you covered with the latest updates and the best pre-registration offers in MO.

Sports Betting Deals Available for Friday

To make the most of Friday's mammoth day of sports, headlined by the The Open Championship golf tournament, check out details on the latest BetMGM bonus code "DIMERS150" that scores you the choice of two outstanding signup offers. Don't miss out!

Conclusion

We predict a close game between the Cardinals and Diamondbacks on Friday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest predictions for the World Series, American League, National League and each division.