St. John's vs. DePaul Prediction: St. John's Predicted to Win College Basketball Matchup [2/19/2025]

DePaul will square off with the favored St. John's in college basketball action at Wintrust Arena on Wednesday, commencing at 9:00PM ET.

Based on updated simulations, Dimers' advanced college basketball model (see Dimers Pro for full access) projects St. John's as the most likely winner of today's game.

Check the latest March Madness bracket projections and 2025 NCAA Championship probabilities.

"Our team has simulated the outcome of Wednesday's St. John's-DePaul game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate St. John's' chance of winning at 84%, with DePaul at 16%."

For further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive St. John's vs. DePaul predictions page.

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St. John's vs. DePaul Prediction: Who Will Win, Cover the Spread?

Using trusted machine learning and data, we have simulated the outcome of Wednesday's NCAA basketball game between St. John's and DePaul 10,000 times as part of our college basketball predictions coverage.

Our independent predictive model gives St. John's an 84% chance of defeating DePaul. Our predicted final score has St. John's winning 77-66.

According to our model, DePaul (+11.5) has a 56% chance of covering the spread, while the 142.5-point over/under has a 52% chance of staying under.

St. John's vs. DePaul Odds

We have sourced the best College Basketball odds in America for this game, which are listed here:

Bet Type	St. John's	DePaul
Spread	-11.5 (-102)	+11.5 (-110)
Moneyline	-670	+550
Total	o142.5 (-115)	u142.5 (-105)

All odds are correct at the time of publication and are subject to change.

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St. John's vs. DePaul Picks and Best Bets

Our model's biggest edge in today's St. John's vs. DePaul matchup is on the total.

Our expert predictions, aligned with the latest odds, reveal the best college basketball picks for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

St. John's vs. DePaul Game-Day Updates and Essential Details

Wednesday's college basketball matchup between DePaul and St. John's at Wintrust Arena is scheduled to begin at 9:00PM ET.

• Who: St. John's vs. DePaul
• Date: Wednesday, February 19, 2025
• Time: 9:00PM ET/6:00PM PT
• Venue: Wintrust Arena

Dimers.com's full preview of Wednesday's St. John's vs. DePaul matchup includes our prediction, picks and the latest betting odds.

Before making any St. John's vs. DePaul picks, be sure to check out the latest college basketball predictions and betting advice from Dimers Pro.

Conclusion

We predict St. John's, with an 84% win probability, will likely beat DePaul on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate St. John's vs. DePaul insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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