Southern University vs. Mississippi Valley State prediction: Why Southern University is favored to win in college football Week 1, 2025

Mississippi Valley State and Southern University will clash in college football action at Rice-Totten Stadium on Saturday, commencing at 5:00PM ET.

Based on updated simulations, Dimers' advanced college football model predicts Southern University as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Southern University vs. Mississippi Valley State predictions page.

Southern University vs. Mississippi Valley State prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the result of Southern University vs. Mississippi Valley State 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Southern University a 78% chance of defeating Mississippi Valley State. Our predicted final score has Southern University winning 30-19.

According to our model, Mississippi Valley State (+13.5) has a 53% chance of covering the spread, while the over/under total of 49.5 points has an equal 50-50 chance of hitting.

Southern University vs. Mississippi Valley State odds

We have researched the best College Football odds in America for this game, which are listed here:

Bet Type	Southern University	Mississippi Valley State
Spread	-13.5 (-110)	+13.5 (-110)
Moneyline	-465	+380
Total	o49.5 (-110)	u49.5 (-110)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Southern University vs. Mississippi Valley State picks and best bets

Our model's strongest edge in today's Southern University vs. Mississippi Valley State matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Southern University vs. Mississippi Valley State game-day updates and essential details

Saturday's college football matchup between Mississippi Valley State and Southern University at Rice-Totten Stadium is scheduled to begin at 5:00PM ET.

• Who: Southern University vs. Mississippi Valley State
• Date: Saturday, August 30, 2025
• Time: 5:00PM ET/2:00PM PT
• Venue: Rice-Totten Stadium

Dimers.com's full preview of Saturday's Southern University vs. Mississippi Valley State matchup includes our prediction, picks and the latest betting odds.

Before making any Southern University vs. Mississippi Valley State picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Sports betting deal available for NCAAF Saturday

Another way to make the most of Saturday's massive day of sports, headlined by college football Saturday games, check out details on the latest Bet365 bonus code "DIMERS" that scores you $200 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict Southern University, with a 78% win probability, will likely beat Mississippi Valley State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Southern University vs. Mississippi Valley State insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on College Football

Keep up with the latest college football news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds offer the most accurate projections for the national title game and major conferences.