Southern Miss vs. Louisiana Tech prediction: Louisiana Tech favored to win in college football Week 4, 2025

Louisiana Tech will square off with Southern Miss in Week 4 college football action at Joe Aillet Stadium on Saturday, with kickoff at 7:30PM ET.

Based on updated simulations, Dimers' advanced college football model predicts Louisiana Tech as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Southern Miss vs. Louisiana Tech predictions page.

Southern Miss vs. Louisiana Tech prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the outcome of Southern Miss vs. Louisiana Tech 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Louisiana Tech a 59% chance of defeating Southern Miss. Our predicted final score has Louisiana Tech winning 26-23.

According to our model, Louisiana Tech (-3) has a 53% chance of covering the spread, while the 51.5-point over/under has an equal 50-50 chance of hitting.

Southern Miss vs. Louisiana Tech odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Southern Miss	Louisiana Tech
Spread	+3 (-102)	-3 (-112)
Moneyline	+135	-152
Total	o51.5 (-110)	u51.5 (-108)

All odds are correct at the time of publication and are subject to change.

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Southern Miss vs. Louisiana Tech picks and best bets

Our model's strongest edge in today's Southern Miss vs. Louisiana Tech matchup is on the total.

Our expert predictions, matched against the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Southern Miss vs. Louisiana Tech game-day updates and essential details

Saturday's college football action between Louisiana Tech and Southern Miss at Joe Aillet Stadium is scheduled to start at 7:30PM ET.

• Who: Southern Miss vs. Louisiana Tech
• Date: Saturday, September 20, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: Joe Aillet Stadium

Dimers' full preview of Saturday's Southern Miss vs. Louisiana Tech matchup includes our prediction, picks and the latest betting odds.

Before making any Southern Miss vs. Louisiana Tech picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Louisiana Tech, with a 59% win probability, will likely beat Southern Miss on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Southern Miss vs. Louisiana Tech insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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