Southern Methodist vs. TCU prediction: Why TCU is favored to win in college football Week 4, 2025

TCU and Southern Methodist will meet in Week 4 college football action at Amon G. Carter Stadium on Saturday, with kickoff at 12:00PM ET.

Based on the latest simulation results, Dimers' advanced college football model predicts TCU as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Southern Methodist vs. TCU predictions page.

Southern Methodist vs. TCU prediction: Who will win, cover the spread?

Using powerful machine learning and statistical analysis, we have simulated the result of Southern Methodist vs. TCU 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives TCU a 64% chance of beating Southern Methodist. Our predicted final score has TCU winning 35-28.

According to our model, the bookmakers have got it right, and Southern Methodist and TCU each have a 50% chance of covering the spread, while the over/under total of 63.5 points also has an equal 50-50 chance of hitting.

Southern Methodist vs. TCU odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Southern Methodist	TCU
Spread	+6.5 (-105)	-6.5 (-114)
Moneyline	+200	-238
Total	o63.5 (-108)	u63.5 (-110)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Southern Methodist vs. TCU picks and best bets

Our model's strongest edge in today's Southern Methodist vs. TCU matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Southern Methodist vs. TCU game-day updates and essential details

Saturday's college football game between TCU and Southern Methodist at Amon G. Carter Stadium is scheduled to start at 12:00PM ET.

• Who: Southern Methodist vs. TCU
• Date: Saturday, September 20, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Amon G. Carter Stadium

Dimers' full preview of Saturday's Southern Methodist vs. TCU matchup includes our prediction, picks and the latest betting odds.

Before making any Southern Methodist vs. TCU picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Sports betting deal available for NCAAF Saturday

To make the most of Saturday's exciting day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that secures $200 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict TCU, with a 64% win probability, will likely beat Southern Methodist on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Southern Methodist vs. TCU insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on college football

Stay up-to-date with the latest college football betting news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds provide the latest predictions for the national title game and major conferences.