Southern Illinois vs. Tennessee-Martin prediction: Why Tennessee-Martin is favored to win in college football Week 3, 2025

Tennessee-Martin will take on Southern Illinois in Week 3 college football action at Hardy M. Graham Stadium on Saturday, starting at 7:00PM ET.

Based on updated simulation results, Dimers' proven college football model predicts Tennessee-Martin as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Southern Illinois vs. Tennessee-Martin predictions page.

Southern Illinois vs. Tennessee-Martin prediction: Who will win, cover the spread?

Using trusted machine learning and data analysis, we have simulated the outcome of Southern Illinois vs. Tennessee-Martin 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Tennessee-Martin a 52% chance of defeating Southern Illinois. Our predicted final score has Tennessee-Martin winning 25-24.

According to our model, Tennessee-Martin (+2.5) has a 54% chance of covering the spread, while the over/under total of 53.5 points has a 58% chance of going over.

Southern Illinois vs. Tennessee-Martin odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Southern Illinois	Tennessee-Martin
Spread	-2.5 (-120)	+2.5 (-102)
Moneyline	-138	+140
Total	o53.5 (-110)	u53.5 (-110)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Southern Illinois vs. Tennessee-Martin picks and best bets

Our model's biggest edge in today's Southern Illinois vs. Tennessee-Martin matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Southern Illinois vs. Tennessee-Martin game-day updates and essential details

Saturday's college football matchup between Tennessee-Martin and Southern Illinois at Hardy M. Graham Stadium is scheduled to begin at 7:00PM ET.

• Who: Southern Illinois vs. Tennessee-Martin
• Date: Saturday, September 13, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Hardy M. Graham Stadium

Dimers' in-depth preview of Saturday's Southern Illinois vs. Tennessee-Martin matchup includes our prediction, picks and the latest betting odds.

Before making any Southern Illinois vs. Tennessee-Martin picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Sports betting deal available for Maryland sports fans

To make the most of Saturday's big day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that scores you $300 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict Tennessee-Martin, with a 52% win probability, will likely beat Southern Illinois on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Southern Illinois vs. Tennessee-Martin insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on college football

Keep up with the latest college football betting news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds offer the most accurate projections for the national title game and major conferences.