Southern Illinois vs. Southeast Missouri State prediction: Southern Illinois favored to win in college football Week 4, 2025

Southeast Missouri State will square off with the favored Southern Illinois in Week 4 college football action at Houck Field on Saturday, commencing at 7:00PM ET.

Based on updated simulation results, Dimers' advanced college football model predicts Southern Illinois as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Southern Illinois vs. Southeast Missouri State predictions page.

Southern Illinois vs. Southeast Missouri State prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the result of Southern Illinois vs. Southeast Missouri State 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Southern Illinois a 65% chance of defeating Southeast Missouri State. Our predicted final score has Southern Illinois winning 28-22.

According to our model, Southeast Missouri State (+6.5) has a 52% chance of covering the spread, while the over/under total of 54.5 points has a 57% chance of going over.

Southern Illinois vs. Southeast Missouri State odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Southern Illinois	Southeast Missouri State
Spread	-6.5 (-108)	+6.5 (-110)
Moneyline	-205	+195
Total	o54.5 (-110)	u54.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Southern Illinois vs. Southeast Missouri State picks and best bets

Our model's strongest edge in today's Southern Illinois vs. Southeast Missouri State matchup is on the spread.

Our expert predictions, matched against the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Southern Illinois vs. Southeast Missouri State game-day updates and essential details

Saturday's college football game between Southeast Missouri State and Southern Illinois at Houck Field is scheduled to start at 7:00PM ET.

• Who: Southern Illinois vs. Southeast Missouri State
• Date: Saturday, September 20, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Houck Field

Dimers' comprehensive preview of Saturday's Southern Illinois vs. Southeast Missouri State matchup includes our prediction, picks and the latest betting odds.

Before making any Southern Illinois vs. Southeast Missouri State picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Southern Illinois, with a 65% win probability, will likely beat Southeast Missouri State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Southern Illinois vs. Southeast Missouri State insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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