Southern Illinois vs. Purdue prediction: Why Purdue is favored to win in college football Week 2, 2025

Purdue and Southern Illinois will lock horns in Week 2 college football action at Ross-Ade Stadium on Saturday, commencing at 7:30PM ET.

Based on updated simulation results, Dimers' advanced college football model predicts Purdue as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Southern Illinois vs. Purdue predictions page.

Southern Illinois vs. Purdue prediction: Who will win, cover the spread?

Using powerful machine learning and data analysis, we have simulated the outcome of Southern Illinois vs. Purdue 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Purdue a 92% chance of beating Southern Illinois. Our predicted final score has Purdue winning 35-15.

According to our model, Purdue (-19.5) has a 53% chance of covering the spread, while the over/under total of 51.5 points has a 56% chance of going over.

Southern Illinois vs. Purdue odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Southern Illinois	Purdue
Spread	+19.5 (-115)	-19.5 (-115)
Moneyline	+810	-1300
Total	o51.5 (-110)	u51.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Southern Illinois vs. Purdue picks and best bets

Our model's strongest edge in today's Southern Illinois vs. Purdue matchup is on the spread.

Our expert predictions, matched against the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Southern Illinois vs. Purdue game-day updates and essential details

Saturday's college football action between Purdue and Southern Illinois at Ross-Ade Stadium is scheduled to begin at 7:30PM ET.

• Who: Southern Illinois vs. Purdue
• Date: Saturday, September 6, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: Ross-Ade Stadium

Dimers.com's full preview of Saturday's Southern Illinois vs. Purdue matchup includes our prediction, picks and the latest betting odds.

Before making any Southern Illinois vs. Purdue picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Purdue, with a 92% win probability, will likely beat Southern Illinois on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Southern Illinois vs. Purdue insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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