Southern California vs. Illinois prediction: Why Southern California is favored to win in college football Week 5, 2025

Illinois and Southern California will lock horns in Week 5 college football action at Memorial Stadium on Saturday, with kickoff at 12:00PM ET.

Based on the latest simulation results, Dimers' proven college football model predicts Southern California as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Southern California vs. Illinois predictions page.

Southern California vs. Illinois prediction: Who will win, cover the spread?

Using trusted machine learning and data analysis, we have simulated the result of Southern California vs. Illinois 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Southern California a 65% chance of beating Illinois. Our predicted final score has Southern California winning 32-26.

According to our model, Southern California (-4.5) has a 54% chance of covering the spread, while the 55.5-point over/under has a 68% chance of going over.

Southern California vs. Illinois odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Southern California	Illinois
Spread	-4.5 (-110)	+4.5 (-120)
Moneyline	-195	+230
Total	o55.5 (-120)	u55.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Southern California vs. Illinois picks and best bets

Our model's strongest edge in today's Southern California vs. Illinois matchup is on the spread.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Southern California vs. Illinois game-day updates and essential details

Saturday's college football game between Illinois and Southern California at Memorial Stadium is scheduled to begin at 12:00PM ET.

• Who: Southern California vs. Illinois
• Date: Saturday, September 27, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Memorial Stadium

Dimers' full preview of Saturday's Southern California vs. Illinois matchup includes our prediction, picks and the latest betting odds.

Before making any Southern California vs. Illinois picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Southern California, with a 65% win probability, will likely beat Illinois on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Southern California vs. Illinois insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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