Southeastern Louisiana vs. LSU prediction: LSU favored to win in college football Week 4, 2025

LSU and Southeastern Louisiana will lock horns in Week 4 college football action at Tiger Stadium on Saturday, beginning at 7:45PM ET.

Based on the latest simulations, Dimers' advanced college football model predicts LSU as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Southeastern Louisiana vs. LSU predictions page.

Southeastern Louisiana vs. LSU prediction: Who will win, cover the spread?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Southeastern Louisiana vs. LSU 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives LSU a 100% chance of beating Southeastern Louisiana. Our predicted final score has LSU winning 54-6.

According to our model, the bookmakers have got it right, and Southeastern Louisiana and LSU each have a 50% chance of covering the spread, while the 59.5-point over/under has a 53% chance of going over.

Southeastern Louisiana vs. LSU odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Southeastern Louisiana	LSU
Spread	+48.5 (-102)	-48.5 (-108)
Moneyline	+8000	-100000
Total	o59.5 (-110)	u59.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Southeastern Louisiana vs. LSU picks and best bets

Our model's strongest edge in today's Southeastern Louisiana vs. LSU matchup is on the spread.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Southeastern Louisiana vs. LSU game-day updates and essential details

Saturday's college football action between LSU and Southeastern Louisiana at Tiger Stadium is scheduled to commence at 7:45PM ET.

• Who: Southeastern Louisiana vs. LSU
• Date: Saturday, September 20, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Tiger Stadium

Dimers' full preview of Saturday's Southeastern Louisiana vs. LSU matchup includes our prediction, picks and the latest betting odds.

Before making any Southeastern Louisiana vs. LSU picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict LSU, with a 100% win probability, will likely beat Southeastern Louisiana on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Southeastern Louisiana vs. LSU insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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