South Florida vs. Florida prediction: Florida favored to win in college football Week 2, 2025

Florida and South Florida will lock horns in Week 2 college football action at Ben Hill Griffin Stadium on Saturday, with kickoff at 4:15PM ET.

Based on updated simulations, Dimers' proven college football model predicts Florida as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive South Florida vs. Florida predictions page.

South Florida vs. Florida prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the outcome of South Florida vs. Florida 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Florida an 88% chance of beating South Florida. Our predicted final score has Florida winning 36-18.

According to our model, the bookmakers have got it right, and South Florida and Florida each have a 50% chance of covering the spread, while the over/under total of 57.5 points has a 56% chance of going over.

South Florida vs. Florida odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	South Florida	Florida
Spread	+18.5 (-112)	-18.5 (-105)
Moneyline	+650	-950
Total	o57.5 (-110)	u57.5 (-105)

All odds are correct at the time of publication and are subject to change.

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South Florida vs. Florida picks and best bets

Our model's biggest edge in today's South Florida vs. Florida matchup is on the spread.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

South Florida vs. Florida game-day updates and essential details

Saturday's college football action between Florida and South Florida at Ben Hill Griffin Stadium is scheduled to begin at 4:15PM ET.

• Who: South Florida vs. Florida
• Date: Saturday, September 6, 2025
• Time: 4:15PM ET/1:15PM PT
• Venue: Ben Hill Griffin Stadium

Dimers.com's in-depth preview of Saturday's South Florida vs. Florida matchup includes our prediction, picks and the latest betting odds.

Before making any South Florida vs. Florida picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Florida, with an 88% win probability, will likely beat South Florida on Saturday.

AI and automation have enhanced this article to quickly deliver accurate South Florida vs. Florida insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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