South Dakota vs. North Dakota State prediction: North Dakota State favored to win in college football Week 5, 2025

North Dakota State will face South Dakota in Week 5 college football action at Gate City Bank Field at the Fargodome on Saturday, beginning at 2:00PM ET.

Based on the latest simulations, Dimers' proven college football model predicts North Dakota State as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive South Dakota vs. North Dakota State predictions page.

South Dakota vs. North Dakota State prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the outcome of South Dakota vs. North Dakota State 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives North Dakota State a 95% chance of defeating South Dakota. Our predicted final score has North Dakota State winning 38-13.

According to our model, North Dakota State (-24.5) has a 52% chance of covering the spread, while the over/under total of 50.5 points has a 53% chance of staying under.

South Dakota vs. North Dakota State odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	South Dakota	North Dakota State
Spread	+24.5 (-105)	-24.5 (-108)
Moneyline	+1700	-4000
Total	o50.5 (-110)	u50.5 (-110)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

South Dakota vs. North Dakota State picks and best bets

Our model's strongest edge in today's South Dakota vs. North Dakota State matchup is on the spread.

Our expert predictions, matched against the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

South Dakota vs. North Dakota State game-day updates and essential details

Saturday's college football action between North Dakota State and South Dakota at Gate City Bank Field at the Fargodome is scheduled to commence at 2:00PM ET.

• Who: South Dakota vs. North Dakota State
• Date: Saturday, September 27, 2025
• Time: 2:00PM ET/11:00AM PT
• Venue: Gate City Bank Field at the Fargodome

Dimers' comprehensive preview of Saturday's South Dakota vs. North Dakota State matchup includes our prediction, picks and the latest betting odds.

Before making any South Dakota vs. North Dakota State picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict North Dakota State, with a 95% win probability, will likely beat South Dakota on Saturday.

AI and automation have enhanced this article to quickly deliver accurate South Dakota vs. North Dakota State insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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