South Dakota vs. Iowa State prediction: Why Iowa State is favored to win in college football Week 1, 2025

Iowa State will face South Dakota in college football action at Jack Trice Stadium on Saturday, with kickoff at 3:30PM ET.

Based on the latest simulations, Dimers' advanced college football model projects Iowa State as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive South Dakota vs. Iowa State predictions page.

South Dakota vs. Iowa State prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the result of South Dakota vs. Iowa State 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives Iowa State an 84% chance of beating South Dakota. Our predicted final score has Iowa State winning 31-17.

According to our model, South Dakota (+15.5) has a 55% chance of covering the spread, while the over/under total of 47.5 points has a 55% chance of staying under.

South Dakota vs. Iowa State odds

We have researched the best College Football odds in America for this game, which are listed here:

Bet Type	South Dakota	Iowa State
Spread	+15.5 (-105)	-15.5 (-115)
Moneyline	+650	-800
Total	o47.5 (-110)	u47.5 (-105)

All odds are correct at the time of publication and are subject to change.

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South Dakota vs. Iowa State picks and best bets

Our model's strongest edge in today's South Dakota vs. Iowa State matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

South Dakota vs. Iowa State game-day updates and essential details

Saturday's college football game between Iowa State and South Dakota at Jack Trice Stadium is scheduled to begin at 3:30PM ET.

• Who: South Dakota vs. Iowa State
• Date: Saturday, August 30, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Jack Trice Stadium

Dimers.com's comprehensive preview of Saturday's South Dakota vs. Iowa State matchup includes our prediction, picks and the latest betting odds.

Before making any South Dakota vs. Iowa State picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Iowa State, with an 84% win probability, will likely beat South Dakota on Saturday.

AI and automation have enhanced this article to quickly deliver accurate South Dakota vs. Iowa State insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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