South Carolina vs. Missouri prediction: Why Missouri is favored to win in college football Week 4, 2025

Missouri and South Carolina will clash in Week 4 college football action at Memorial Stadium/Faurot Field on Saturday, starting at 7:00PM ET.

Based on updated simulation results, Dimers' proven college football model predicts Missouri as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive South Carolina vs. Missouri predictions page.

South Carolina vs. Missouri prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the outcome of South Carolina vs. Missouri 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Missouri a 67% chance of beating South Carolina. Our predicted final score has Missouri winning 29-23.

According to our model, South Carolina (+9.5) has a 58% chance of covering the spread, while the 48.5-point over/under has a 56% chance of staying under.

South Carolina vs. Missouri odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	South Carolina	Missouri
Spread	+9.5 (-102)	-9.5 (-120)
Moneyline	+285	-350
Total	o48.5 (-110)	u48.5 (-110)

All odds are correct at the time of publication and are subject to change.

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South Carolina vs. Missouri picks and best bets

Our model's biggest edge in today's South Carolina vs. Missouri matchup is on the over/under.

Our expert predictions, aligned with the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

South Carolina vs. Missouri game-day updates and essential details

Saturday's college football game between Missouri and South Carolina at Memorial Stadium/Faurot Field is scheduled to start at 7:00PM ET.

• Who: South Carolina vs. Missouri
• Date: Saturday, September 20, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Memorial Stadium/Faurot Field

Dimers' in-depth preview of Saturday's South Carolina vs. Missouri matchup includes our prediction, picks and the latest betting odds.

Before making any South Carolina vs. Missouri picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Missouri, with a 67% win probability, will likely beat South Carolina on Saturday.

AI and automation have enhanced this article to quickly deliver accurate South Carolina vs. Missouri insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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