South Carolina State vs. South Florida prediction: South Florida favored to win in college football Week 4, 2025

South Florida will face South Carolina State in Week 4 college football action at Raymond James Stadium on Saturday, starting at 12:00PM ET.

Based on the latest simulation results, Dimers' advanced college football model projects South Florida as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive South Carolina State vs. South Florida predictions page.

South Carolina State vs. South Florida prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the outcome of South Carolina State vs. South Florida 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives South Florida a 99% chance of defeating South Carolina State. Our predicted final score has South Florida winning 46-9.

According to our model, the bookmakers have got it right, and South Carolina State and South Florida each have a 50% chance of covering the spread, while the 56.5-point over/under has a 53% chance of going over.

South Carolina State vs. South Florida odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	South Carolina State	South Florida
Spread	+36.5 (-105)	-36.5 (-110)
Moneyline	+7000	-20000
Total	o56.5 (-110)	u56.5 (-110)

All odds are correct at the time of publication and are subject to change.

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South Carolina State vs. South Florida picks and best bets

Our model's biggest edge in today's South Carolina State vs. South Florida matchup is on the spread.

Our expert predictions, matched against the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

South Carolina State vs. South Florida game-day updates and essential details

Saturday's college football game between South Florida and South Carolina State at Raymond James Stadium is scheduled to start at 12:00PM ET.

• Who: South Carolina State vs. South Florida
• Date: Saturday, September 20, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Raymond James Stadium

Dimers' comprehensive preview of Saturday's South Carolina State vs. South Florida matchup includes our prediction, picks and the latest betting odds.

Before making any South Carolina State vs. South Florida picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict South Florida, with a 99% win probability, will likely beat South Carolina State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate South Carolina State vs. South Florida insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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