South Carolina State vs. South Carolina prediction: South Carolina favored to win in college football Week 2, 2025

South Carolina will take on South Carolina State in Week 2 college football action at Williams-Brice Stadium on Saturday, beginning at 7:00PM ET.

Based on updated simulations, Dimers' proven college football model predicts South Carolina as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive South Carolina State vs. South Carolina predictions page.

South Carolina State vs. South Carolina prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the result of South Carolina State vs. South Carolina 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives South Carolina a 100% chance of beating South Carolina State. Our predicted final score has South Carolina winning 47-4.

According to our model, the bookmakers have got it right, and South Carolina State and South Carolina each have a 50% chance of covering the spread, while the over/under total of 52.5 points has a 56% chance of going over.

South Carolina State vs. South Carolina odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	South Carolina State	South Carolina
Spread	+42.5 (-110)	-42.5 (-110)
Moneyline	+8000	-100000
Total	o52.5 (-110)	u52.5 (-110)

All odds are correct at the time of publication and are subject to change.

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South Carolina State vs. South Carolina picks and best bets

Our model's strongest edge in today's South Carolina State vs. South Carolina matchup is on the spread.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

South Carolina State vs. South Carolina game-day updates and essential details

Saturday's college football matchup between South Carolina and South Carolina State at Williams-Brice Stadium is scheduled to begin at 7:00PM ET.

• Who: South Carolina State vs. South Carolina
• Date: Saturday, September 6, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Williams-Brice Stadium

Dimers.com's full preview of Saturday's South Carolina State vs. South Carolina matchup includes our prediction, picks and the latest betting odds.

Before making any South Carolina State vs. South Carolina picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict South Carolina, with a 100% win probability, will likely beat South Carolina State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate South Carolina State vs. South Carolina insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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