South Carolina State vs. Charleston Southern prediction: Why South Carolina State is favored to win in college football Week 5, 2025

Charleston Southern and South Carolina State will lock horns in Week 5 college football action at Buccaneer Field on Saturday, beginning at 6:00PM ET.

Based on updated simulation results, Dimers' proven college football model predicts South Carolina State as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive South Carolina State vs. Charleston Southern predictions page.

South Carolina State vs. Charleston Southern prediction: Who will win, cover the spread?

Using powerful machine learning and data analysis, we have simulated the outcome of South Carolina State vs. Charleston Southern 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives South Carolina State a 70% chance of defeating Charleston Southern. Our predicted final score has South Carolina State winning 30-22.

According to our model, Charleston Southern (+10.5) has a 56% chance of covering the spread, while the 50.5-point over/under has a 54% chance of staying under.

South Carolina State vs. Charleston Southern odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	South Carolina State	Charleston Southern
Spread	-10.5 (-110)	+10.5 (-110)
Moneyline	-360	+310
Total	o50.5 (-118)	u50.5 (-102)

All odds are correct at the time of publication and are subject to change.

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South Carolina State vs. Charleston Southern picks and best bets

Our model's strongest edge in today's South Carolina State vs. Charleston Southern matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

South Carolina State vs. Charleston Southern game-day updates and essential details

Saturday's college football action between Charleston Southern and South Carolina State at Buccaneer Field is scheduled to commence at 6:00PM ET.

• Who: South Carolina State vs. Charleston Southern
• Date: Saturday, September 27, 2025
• Time: 6:00PM ET/3:00PM PT
• Venue: Buccaneer Field

Dimers' comprehensive preview of Saturday's South Carolina State vs. Charleston Southern matchup includes our prediction, picks and the latest betting odds.

Before making any South Carolina State vs. Charleston Southern picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict South Carolina State, with a 70% win probability, will likely beat Charleston Southern on Saturday.

AI and automation have enhanced this article to quickly deliver accurate South Carolina State vs. Charleston Southern insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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