Seattle Seahawks vs. Pittsburgh Steelers early prediction: Expert picks for NFL Week 2, 2025

The Seattle Seahawks and Pittsburgh Steelers will meet in Week 2 of the NFL season at Acrisure Stadium on Sunday, September 14, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Steelers as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Seahawks vs. Steelers predictions page.

Seattle vs. Pittsburgh early predictions

Leveraging trusted machine learning and analysis, we have simulated the Seahawks vs. Steelers game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Seahawks 41%, Steelers 59%
• Predicted final score: Seahawks 20-22 Steelers
• Spread: Seahawks (+2.5) 50%, Steelers (-2.5) 50%
• Total points (42.5): Over 50%, Under 50%

As of September 7, 2025, these Seahawks-Steelers numbers and predictions reflect the latest data and insights available.

Seahawks vs. Steelers Week 2 details

The NFL Week 2 game between the Steelers and Seahawks at Acrisure Stadium is scheduled for September 14, 2025.

• Who: Seattle Seahawks vs. Pittsburgh Steelers
• Date: Sunday, September 14, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Acrisure Stadium

Seahawks vs. Steelers opening odds

We've researched the best betting odds across America for this Week 2 game, which are listed here:

• Spread: Seahawks +2.5 (-110), Steelers -2.5 (-110)
• Moneyline: Seahawks +114, Steelers -135
• Total: Over/Under 42.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Steelers, with a 59% win probability, will likely beat the Seahawks in Week 2 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Seahawks vs. Steelers matchup, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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