Seahawks vs. Cardinals prediction: Why Seattle is favored to win TNF Week 4, 2025

The Arizona Cardinals will face the Seattle Seahawks in NFL Week 4 action at State Farm Stadium on Thursday, starting at 8:15PM ET.

Based on the latest simulations, Dimers' advanced NFL model predicts the Seahawks as the most likely winner of today's game.

This gameday Seahawks vs. Cardinals betting preview builds on my early Seahawks vs. Cardinals prediction that was published earlier in the week.

For a closer look at today’s game, including the predicted score, best bets and player prop picks, visit our interactive Seahawks vs. Cardinals predictions page.

Seahawks vs. Cardinals Predictions

Since our Seahawks-Cardinals predictions earlier in the week, we have simulated the outcome of Thursday's NFL matchup between the Seahawks and Cardinals 10,000 times as part of our NFL predictions coverage.

Our leading predictive model currently gives the Seahawks a 58% chance of defeating the Cardinals in Week 4 of the NFL season. Our predicted final score has the Seahawks winning 22-20.

According to our model, the bookmakers have got it right, and the Seahawks and Cardinals each have a 50% chance of covering the spread, while the over/under total of 43.5 points has a 54% chance of staying under.

Seahawks vs. Cardinals odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type	Seahawks	Cardinals
Spread	-1.5 (-106)	+1.5 (-110)
Moneyline	-120	+105
Total	o43.5 (-110)	u43.5 (-108)

All odds are correct at the time of publication and are subject to change.

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Seahawks vs. Cardinals picks and best bets

Our model's strongest edge in today's Seahawks vs. Cardinals matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Seahawks vs. Cardinals TD scorers

Who will score an anytime touchdown in Seahawks vs. Cardinals?

According to our model, Seattle's Kenneth Walker is most likely to score the first TD in Seahawks vs. Cardinals.

Our projections give Walker an 11.5% chance of scoring the first TD at State Farm Stadium, while the Seahawks running back is a 46.3% chance of reaching the end zone at any point during the game.

First touchdown scorer predictions

Seattle Seahawks

Player	First TD Probability
Kenneth Walker (RB)	11.5%
Jaxon Smith-Njigba (WR)	8.4%
Zach Charbonnet (RB)	7.9%

Arizona Cardinals

Player	First TD Probability
Trey Benson (RB)	10.1%
Marvin Harrison (WR)	7.9%
Trey McBride (TE)	7.8%

Anytime touchdown scorer predictions

Seattle Seahawks

Player	Anytime TD Probability
Kenneth Walker (RB)	46.3%
Jaxon Smith-Njigba (WR)	36.6%
Zach Charbonnet (RB)	34.7%

Arizona Cardinals

Player	Anytime TD Probability
Trey Benson (RB)	37.1%
Marvin Harrison (WR)	30.3%
Trey McBride (TE)	30.1%

Seahawks vs Cardinals player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Seahawks and Cardinals. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Seahawks-Cardinals page now to access every player prop projection.

Seahawks vs. Cardinals quarterbacks

Of the starting quarterbacks, the Seahawks' Sam Darnold is projected to throw for more yards than the Cardinals' Kyler Murray.

Seahawks rushing

Kenneth Walker, Zach Charbonnet and Sam Darnold are projected to be the leading rushers for the Seahawks.

Player	Position
Kenneth Walker	RB
Zach Charbonnet	RB
Sam Darnold	QB

Cardinals rushing

Trey Benson, Kyler Murray and Emari Demercado are expected to lead the Cardinals in rushing yards.

Player	Position
Trey Benson	RB
Kyler Murray	QB
Emari Demercado	RB

Seahawks receiving

Jaxon Smith-Njigba, Cooper Kupp, Tory Horton, AJ Barner and Kenneth Walker are projected to top the receiving yards for the Seahawks.

Player	Position
Jaxon Smith-Njigba	WR
Cooper Kupp	WR
Tory Horton	WR
AJ Barner	TE
Kenneth Walker	RB

Cardinals receiving

Trey McBride, Marvin Harrison, Michael Wilson, Trey Benson and Greg Dortch are projected to lead the Cardinals in receiving yards.

Player	Position
Trey McBride	TE
Marvin Harrison	WR
Michael Wilson	WR
Trey Benson	RB
Greg Dortch	WR

Seahawks vs. Cardinals game-day updates and essential details

The NFL Week 4 action between the Cardinals and Seahawks at State Farm Stadium is scheduled to commence at 8:15PM ET.

• Who: Seattle Seahawks vs. Arizona Cardinals
• Date: Thursday, September 25, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: State Farm Stadium

Dimers' comprehensive preview of this week's Seahawks vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Seahawks vs. Cardinals picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Seahawks, with a 58% win probability, will likely beat the Cardinals in Week 4 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Seahawks vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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