Seattle Seahawks vs. Arizona Cardinals early prediction: Expert picks for NFL Week 4, 2025

The Seattle Seahawks and Arizona Cardinals will meet in Week 4 of the NFL season at State Farm Stadium on Thursday, September 25, 2025, starting at 8:15PM ET.

Early simulations from Dimers' trusted NFL model favor the Cardinals as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Seahawks vs. Cardinals predictions page.

Seattle vs. Arizona early predictions

Leveraging trusted machine learning and analysis, we have simulated the Seahawks vs. Cardinals game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Seahawks 41%, Cardinals 59%
• Predicted final score: Seahawks 21-24 Cardinals
• Spread: Seahawks (+2.5) 50%, Cardinals (-2.5) 50%
• Total points (46.5): Over 47%, Under 53%

As of September 21, 2025, these Seahawks-Cardinals numbers and predictions reflect the latest data and insights available.

Seahawks vs. Cardinals Week 4 details

The NFL Week 4 matchup between the Cardinals and Seahawks at State Farm Stadium is scheduled for September 25, 2025.

• Who: Seattle Seahawks vs. Arizona Cardinals
• Date: Thursday, September 25, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: State Farm Stadium

Seahawks vs. Cardinals opening odds

We've researched the best betting odds across America for this Week 4 game, which are listed here:

• Spread: Seahawks +2.5 (-110), Cardinals -2.5 (-108)
• Moneyline: Seahawks +120, Cardinals -140
• Total: Over/Under 46.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Cardinals, with a 59% win probability, will likely beat the Seahawks in Week 4 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Seahawks vs. Cardinals matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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