Mariners vs. Padres Prediction: San Diego Predicted to Win Friday's MLB Matchup [5/16/2025]

MLB action continues on Friday at 9:40PM ET as the Seattle Mariners square off with the San Diego Padres at PETCO Park.

Stephen Kolek (2-0, 0.00 ERA) will start on the mound for the Padres, while the Mariners have opted for Logan Evans (1-1, 3.60 ERA).

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Padres as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Seattle-San Diego game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Padres' chance of winning is 62%, while the Mariners' is 38%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Mariners vs. Padres predictions page.

Padres vs. Mariners Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data analysis, we have simulated the result of Friday's MLB matchup between the Mariners and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Padres a 62% chance of beating the Mariners.

According to our model, the Mariners (+1.5) have a 57% chance of covering the run line, while the 8.5-run over/under has a 51% chance of going over.

Mariners vs. Padres Odds [5/16/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Mariners	Padres
Run Line	+1.5 (-135)	-1.5 (+125)
Moneyline	+150	-170
Total	o8.5 (-120)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Mariners vs. Padres Picks and Best Bets

Our model's biggest edge in today's Mariners vs. Padres matchup is on the over/under.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Mariners vs. Padres Game-Day Updates and Essential Details

Friday's MLB matchup between the Padres and Mariners at PETCO Park is scheduled to start at 9:40PM ET.

• Who: Seattle Mariners vs. San Diego Padres
• Date: Friday, May 16, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's comprehensive preview of Friday's Mariners vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Seattle vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Sports Betting Deals Available for Friday

To make the most of Friday's enormous day of sports, headlined by the opening night of the WNBA season, check out details on the latest Bet365 bonus code "DIMERS" that scores you the choice of two excellent signup promotions. Don't miss out!

Conclusion

We predict the Padres, with a 62% win probability, will likely beat the Mariners on Friday.

AI and automation have enhanced this article to quickly deliver accurate Mariners vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest projections for the World Series, American League, National League and each division.