Mariners vs. Phillies prediction: Philadelphia predicted to win Wednesday's MLB matchup [8/20/2025]

The Philadelphia Phillies will face the Seattle Mariners in MLB action at Citizens Bank Park on Wednesday, commencing at 1:05PM ET.

Jesús Luzardo (11-6, 4.21 ERA) will start on the mound for the Phillies, pitting him against Luis Castillo (8-6, 3.48 ERA) for the Mariners.

Based on the latest simulation results, Dimers' proven MLB model predicts the Phillies as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Mariners-Phillies game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Phillies' chance of winning at 58%, with the Mariners at 42%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Mariners vs. Phillies predictions page.

Phillies vs. Mariners prediction: Who will win, cover the run line?

Using trusted machine learning and data analysis, we have simulated the result of Wednesday's MLB game between the Mariners and Phillies 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Phillies a 58% chance of beating the Mariners.

According to our model, the Mariners (+1.5) have a 60% chance of covering the run line, while the over/under total of 8.5 runs has a 53% chance of going over.

Mariners vs. Phillies odds [8/20/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Mariners	Phillies
Run Line	+1.5 (-167)	-1.5 (+146)
Moneyline	+130	-144
Total	o8.5 (-120)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Mariners vs. Phillies picks and best bets

Our model's biggest edge in today's Mariners vs. Phillies matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

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Mariners vs. Phillies game-day updates and essential details

Wednesday's MLB action between the Phillies and Mariners at Citizens Bank Park is scheduled to commence at 1:05PM ET.

• Who: Seattle Mariners vs. Philadelphia Phillies
• Date: Wednesday, August 20, 2025
• Time: 1:05PM ET/10:05AM PT
• Venue: Citizens Bank Park

Dimers.com's full preview of Wednesday's Mariners vs. Phillies matchup includes our prediction, picks and the latest betting odds.

Before making any Mariners vs. Phillies picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Phillies, with a 58% win probability, will likely beat the Mariners on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Mariners vs. Phillies insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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