Mariners vs. Royals prediction: Kansas City favored to win Wednesday's MLB matchup [9/17/2025]

The Kansas City Royals and Seattle Mariners will meet in MLB action at Kauffman Stadium on Wednesday, starting at 7:40PM ET.

The Royals will send Cole Ragans (2-3, 5.18 ERA) to the mound, pitting him against Bryce Miller (4-5, 5.59 ERA) for the Mariners.

Based on updated simulation results, Dimers' advanced MLB model predicts the Royals as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Mariners-Royals game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Royals' chance of winning at 56%, with the Mariners at 44%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Mariners vs. Royals predictions page.

Royals vs. Mariners prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the Mariners and Royals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Royals a 56% chance of beating the Mariners.

According to our model, the Mariners (+1.5) have a 62% chance of covering the run line, while the over/under total of 8.5 runs has a 53% chance of going over.

Mariners vs. Royals odds [9/17/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Mariners	Royals
Run Line	+1.5 (-200)	-1.5 (+164)
Moneyline	+104	-120
Total	o8.5 (-120)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Mariners vs. Royals picks and best bets

Our model's strongest edge in today's Mariners vs. Royals matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

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Mariners vs. Royals game-day updates and essential details

Wednesday's MLB matchup between the Royals and Mariners at Kauffman Stadium is scheduled to commence at 7:40PM ET.

• Who: Seattle Mariners vs. Kansas City Royals
• Date: Wednesday, September 17, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Kauffman Stadium

Dimers' in-depth preview of Wednesday's Mariners vs. Royals matchup includes our prediction, picks and the latest betting odds.

Before making any Mariners vs. Royals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Royals, with a 56% win probability, will likely beat the Mariners on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Mariners vs. Royals insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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